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They will not face the top three of the list, but will face a total of six of the 10 and also one of the five who received honorable mention. Top-10 RBs the Cardinals will face in 2025 No. 4 Bijan Robinson, Atlanta Falcons (Week 16) No. 5 Christian McCaffrey, San Francisco 49ers (Weeks 3, 11) No. 6 Josh Jacobs, Green Bay Packers (Week 7) No. 7 Jonathan Taylor, Indianapolis Colts (Week 6) No. 9 Joe Mixon, Houston Texans (Week 15) No. 10 Alvin Kamara, New Orleans Saints (Week 1) Honorable mention Bucky Irving, Tampa Bay Buccaneers (Week 13) The Cardinals were 20th in rushing defense last season but 25th in yards per attempt, allowing 4.6 yards per carry. It was a reason why they were dead last plays allowed per drive and second-to-last in time allowed per drive. But with a beefed up defensive line and edge presence, their run defense should be better. Will that be enough to slow this lineup of opposing backs? That is one thing to watch this season. Get more Cardinals and NFL coverage from Cards Wire’s Jess Root and others by listening to the latest on the Rise Up, See Red podcast. Subscribe on

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Arizona Cardinals to face 6 of NFL’s top 10 RBs in 2025Arizona Cardinals running back James Conner came just short…