United host Arsenal at Old Trafford in the 4.30pm kick-off. The game could see several players make their competitive debuts for both sides after summer transfers.
Arsenal have seen six new arrivals, with striker Viktor Gyokeres among them. United were also credited with an interest in the forward this summer.
Ruben Amorim’s side have also been active in the transfer market with the arrivals of Matheus Cunha, Bryan Mbeumo and striker Benjamin Sesko.
United won a transfer battle with Premier League rivals Newcastle United for Sesko, with the Slovenia international completing his move to Old Trafford last week.
Ahead of the first game of the season, the Premier League have a deadline as to the registration of new signings in relation to being able to play in the next game. Players who wish to play in matches must be registered by 12pm on the final working day before the match.
Therefore, for the opening match any new signings must have been registered for 12pm on Friday if they wish to play. With Sesko joining United days earlier, it means that they beat the deadline by a long way and the 22-year-old will be eligible to play against Arsenal on the opening day.
If he starts, as expected, he is likley to be joined by fellow new signings Cunha and Mbeumo in the starting line-up.
Sesko scored 13 times in 33 Bundesliga appearances for RB Leipzig last season. He will be hoping to get off to the perfect start with United and make an instant impression in his first game for the club.
