Jurgen Klopp will take his side to the Etihad Stadium for the 12.30pm kick-off on November 25, hoping to emerge with three points for the first time since 2015.
The two sides have enjoyed some titanic tussles in recent years, with Klopp and Pep Guardiola going head to head 20 times in the seven years both have managed in the Premier League.
With both sides within three points of the top of the Premier League table, the latest chapter in their rivalry could end up playing a significant part in where the trophy resides at the end of May.
Elsewhere, Champions League chasers Aston Villa – only a point behind Liverpool in the table – travel to current league leaders Tottenham on November 26, also exclusively live on Sky Sports. Kick-off is at 2pm.
Goals have flowed when these two sides have met in recent encounters in North London, with 16 scored in the last five meetings at the Tottenham Hotspur Stadium.
With the pair having scored 37 times between them across their first eight games this season, it promises to be another pulsating encounter this time around.
After that the Sky Sports cameras are off to Goodison Park to capture Everton’s game against Manchester United at 4.30pm.
Sean Dyche’s side might be enduring a tough season on the pitch but they have held their own against the Red Devils in recent years on Merseyside, winning two and drawing another of their last five league meetings – including a 4-0 thrashing in 2019.
Rounding off a huge weekend of football, the Monday Night Football will see Fulham host Wolves at Craven Cottage on November 27, kick-off at 8pm.
It will be the first time former Wolves striker Raul Jimenez will have the chance to face his former club since his move to the Cottagers in the summer – as both sides look to push towards the top half of the Premier League table.
